Risk factors and prognosis of surgery for spinal metastasis / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the risk factors and prognosis of surgery for spinal metastasis.</p><p><b>METHODS</b>A retrospective analysis was performed in 63 patients with spinal metastasis who underwent surgical treatment between June 1992 and June 2002. Forty-one patients underwent anterior en-bloc or partial resection, decompression and reconstruction with internal fixation of the spine. Laminectomy and decompression with internal fixation were done in 8 patients. One-stage anterior-posterior en-bloc resection and decompression followed by reconstructive stabilization were done in 14 patients.</p><p><b>RESULTS</b>Having been followed up more than 6 months, postoperative radiological evaluation revealed that spinal stabilization was evident in all patients. Fifty-seven (91.9%) patients benefited with quality of life significantly improved through pain alleviation, 41 (66.1%) patients improved in their neurological status. No serious complications were observed in surgery. The mean survival time after surgery was 6 months in patients with lung and liver carcinoma, 15 months in breast, prostatic, and stomach carcinoma as well as the other miscellaneous malignancies and 28 months in thyroid, kidney carcinoma among which groups the difference were significant (P < 0.01).</p><p><b>CONCLUSION</b>Surgical treatment for spinal metastasis is able to relieve neurological symptoms and improve the quality of life. The survival time is related to the site of primary tumor; shorter survival in lung and liver carcinoma, longer in breast, prostatic, stomach carcinoma and longest in thyroid and kidney carcinoma.</p>