Experimental study on effect of pre-acupuncture and moxibustion on molecular markers in pre-thrombosis state of rats / 中国针灸
Chinese Acupuncture & Moxibustion
;
(12): 845-847, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-254864
ABSTRACT
<p><b>OBJECTIVE</b>To explore the best method for prevention and treatment of thrombosis and its mechanism.</p><p><b>METHODS</b>Forty SD rats were randomly divided into a blank group, a model group, an electroacupuncture group and a crude herb moxibustion group. In the electroacupuncture group and the crude herb moxibustion group. "Zusanli" (ST 36), "Sanyinjiao" (SP 6), "Pishu" (BL 20) and "Geshu" (BL 17) were punctured or moxibusted for 2 weeks, then pre-thrombosis model was induced by Adrenalin Hydrochloride and ice water method in the model group, the electroacupuncture group and the crude herb moxibustion group, respectively. Molecular markers in venous blood after the model made in 18 hours were detected.</p><p><b>RESULTS</b>Act vaty of tissue-type plasminogen activator (t-PA) and content of alpha-granule membrane protein (GMP-140) decreased and content of nitrogen monoxidum (NO) increased after electroacupuncture or crude herb moxibustion. The levels of t-PA and GMP-140 in the model group were higher than those in the electroacupuncture group, the crude herb moxibustion group and the blank group (all P < 0.05), and the content of NO in the model group was lower than those in the electroacupuncture group, the crude herb moxibustion group and the blank group (all P < 0.05), while there was no significant difference in t- PA, GMP-140 and NO among the crude herb moxibustion group, electroacupuncture group and blank group (all P > 0.05).</p><p><b>CONCLUSION</b>Electroacupuncture and crude herb moxibustion can significantly change the contents of t-PA, GMP-140 and NO and there was no significant difference between the two therapies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Thrombosis
/
Blood
/
Random Allocation
/
Acupuncture Therapy
/
Tissue Plasminogen Activator
/
Rats, Sprague-Dawley
/
P-Selectin
/
Disease Models, Animal
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Acupuncture & Moxibustion
Year:
2010
Type:
Article
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