Effect of nano-SiO2 exposure on spatial learning and memory and LTP of hippocampal dentate gyrus in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 78-81, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-254951
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of nano-SiO2 on spatial learning and memory.</p><p><b>METHODS</b>Twenty-four male rats were randomly divided into 3 groups control group (C group), low dose group (L group) and high dose group (H group). The rats were intragastrically administrated with nanometer particles at 25 and 100 mg/kg body weight every day for 4 weeks. After exposure, the ability of learning and memory of rats was tested by Morris water maze, and electrophysiological brain stereotactic method was used to test long-tear potentiation (LTP) in dentate gyrus (DG) of the rats.</p><p><b>RESULTS</b>The increase rate of body weight in H group was reduced significantly compared with C group ( P < 0.05). In the space exploration experiment of Morris water maze test, the escape latency of H group was longer than that of C group (P < 0.05). The rats of H group spent less time in finding the target quadrant (P < 0.05) . The rate of LP induction of H group was significantly lower than that of C group (P < 0.05). After high fre quency stimulation (HFS), The changes of amplitude of population spike (PS) of L group and H group were lower than those of C group significantly (P < 0.05, P < 0.01).</p><p><b>CONCLUSION</b>Nano-SiO₂may result in impairment of spatial learning and memory ability by reducing the rate of LTP induction and the increase of PS in hippocampus.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Long-Term Potentiation
/
Silicon Dioxide
/
Maze Learning
/
Dentate Gyrus
/
Nanoparticles
/
Spatial Learning
/
Memory
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2016
Type:
Article
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