The application of in vivo multi-channel recording methods in the studies of the affective pain in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 41-45, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-254960
ABSTRACT
<p><b>OBJECTIVE</b>To record the electrical activities of Antirior cingulate cortex (ACC) neurons by in vivo multi-channel recording methods using the model of complete freund's adjuvant (CFA) induced conditioned place avoidance (C-CPA), which has been set up in our previous studies.</p><p><b>METHODS</b>The electrode was self-made and the CPA responses were recorded by in vivo multi-channel recording method.</p><p><b>RESULTS</b>(1) The electrical activities of ACC neurons could be successfully recorded by the self-made electrode. (2) Before or after the injection of CFA, rats were respectively conditioned to the different place. The firing rates of ACC neurons in the CFA-paired place vs that in the non-CFA-paired place was (0.853 ± 1.377) imp/s vs (0.221 ± 0.971) imp/s (P < 0.05, n = 26). (3) The CPA responses in the CFA-paired place vs that in the non-CFA-paired place were (303.55 ± 61.77)s vs (140.32 ± 33.52)s(P < 0.05, n = 6).</p><p><b>CONCLUSION</b>The firing rates of rACC (rostral Anterior Cingulate Cortex) neurons were involved in the occurrence of the affective pain.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Pain Measurement
/
Freund's Adjuvant
/
Rats, Sprague-Dawley
/
Cell Biology
/
Diagnosis
/
Electrodes
/
Gyrus Cinguli
/
Methods
/
Neurons
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2016
Type:
Article
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