Effects of rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 18-21, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-254966
ABSTRACT
<p><b>OBJECTIVE</b>The present study investigated the effects of rapamycin on Aβ1-42-induced deficits in working memory and synaptic plasticity.</p><p><b>METHODS</b>After bilateral hippocampal injection of Aβ1-42 and rapamycinin rats, spontaneous alternation in Y-maze and in vivo hippocampal long-term potentiation (LTP) of rats were recorded. All data were analized by two-way repeated measures analysis of variance (ANOVA).</p><p><b>RESULTS</b>(Hippocampal injection of Aβ1-42 alone impaired working memory of rats; (2) Rapamycin did not affect working memory of rats, but alleviated Aβ1-42-induced working memory deficits, compared with Aβ1-42 alone group; (Aβ1-42 remarkably suppressed in vivo hippocampal LTP of fEPSPs in the CA1 region; (4) Pretreatment with rapamycin prevented Aβ1-42-induced suppression of LTP.</p><p><b>CONCLUSION</b>These data indicates that rapamycin could protect against Aβ1-42-induced impairments in working memory and synaptic plasticity in rats.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Pharmacology
/
Amyloid beta-Peptides
/
Long-Term Potentiation
/
Maze Learning
/
Sirolimus
/
Hippocampus
/
Memory, Short-Term
/
Neuronal Plasticity
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2016
Type:
Article
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