Effects of Rhubarbs from different regions on blood lipid and antioxidation of hyperlipidemia rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 278-281, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-255032
ABSTRACT
<p><b>OBJECTIVE</b>To comparatively study the effects of Rhubarbs from different regions on blood lipid and antioxi dation of hyperlipidemia rats.</p><p><b>METHODS</b>Male rats were randomly divided into 9 groups ( n = 8) and fed with high-fat diet to replicate the hyperlipidemia model. Meanwhile, Rheum tanguticum was administrated intragastrically at two doses (3.0 g/kg and 1.0 g/kg), once a day for continuous 28 days. The effects of Rheum tanguticum planted in Gannan (RT-GN), Rheum tanguticum planted in Xinin (RT-XN) and Rheum plmatum planted in Lixian (RP-LX) were evaluated through detecting the parameters of blood lipids, blood viscosity and antioxidant system.</p><p><b>RESULTS</b>T-GN, RT-XN and RP-LX in the range of 1.0-3.0 g/kg could decrease the blood levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and malonaldehyde (MDA) in blood. Besides, they could reduce blood viscosity, increase high density lipoprotein (HDL) level and upregulate the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Interestingly, their effects on blood viscosity was obviously in a dose dependent manner. In addition, the effects of RT-GN on LDL, MDA and blood viscosity were not significantly different from those of RT-XN and better than those of RP-LX.</p><p><b>CONCLUSION</b>The RT has better hypolipidemic effects than the RP, but RT-GN and RT-XN are not different from the above effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Rheum
/
Superoxide Dismutase
/
Triglycerides
/
Blood
/
Blood Viscosity
/
Drugs, Chinese Herbal
/
Chemistry
/
Cholesterol
/
Disease Models, Animal
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2015
Type:
Article
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