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Experimental study on induction of the normal human melanocytes apoptosis in vitro by cycloheximide and TNF-alpha / 中华整形外科杂志
Chinese Journal of Plastic Surgery ; (6): 302-305, 2005.
Article in Chinese | WPRIM | ID: wpr-255047
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of cycloheximide and TNF-alpha on melanocyte (MC).</p><p><b>METHODS</b>Melanocyte apoptosis was studied with MTT, transmitting electron microscopy and fluorescence labeling of alive cells.</p><p><b>RESULTS</b>We added TNF-alpha and cycloheximide in melanocytes, and the typical apoptosis appeared 24 hours later, with chromatin condensation, nuclear pyknosis and apoptotic bodies formation. The results of cytometry showed the typical apoptotic peak.</p><p><b>CONCLUSION</b>TNF-alpha and cycloheximide together could inhibit MC proliferation and induce MC apoptosis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / In Vitro Techniques / Tumor Necrosis Factor-alpha / Apoptosis / Cycloheximide / Cell Biology / Cell Proliferation / Drug Synergism / Melanocytes Limits: Adolescent / Adult / Humans / Male Language: Chinese Journal: Chinese Journal of Plastic Surgery Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / In Vitro Techniques / Tumor Necrosis Factor-alpha / Apoptosis / Cycloheximide / Cell Biology / Cell Proliferation / Drug Synergism / Melanocytes Limits: Adolescent / Adult / Humans / Male Language: Chinese Journal: Chinese Journal of Plastic Surgery Year: 2005 Type: Article