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The relationship between the expression of HIF-1alpha and the angiogenesis in infancy hemangioma / 中华整形外科杂志
Chinese Journal of Plastic Surgery ; (6): 115-118, 2005.
Article in Chinese | WPRIM | ID: wpr-255091
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of HIF-1alpha and its roles on the vascular endothelial cell growth factor (VEGF) and microvessel density (MVD ) in hemangioma.</p><p><b>METHODS</b>Immunohistochemical streptavidin/peroxidase(SP) stain was applied to examine the expression of HIF-1alpha, VEGF and CD34. The amount of microvessel was counted, which the endothelial cell expressed CD34.</p><p><b>RESULTS</b>The nuclei and cytoplasm of the endothelial cell showed positive staining for HIF-1alpha in hemangioma. In 28 cases, positive rate for HIF-1alpha was 64%, for VEGF was 71.4%. In the proliferating phase, positive rate for HIF-1alpha was 87.5%, for VEGF was 93.7%. However, the positive rate for HIF-1alpha, in the involuting phase, was 33.3%, and for VEGF was 41.7%. There was a very significantly different between two phases (P < 0.01). In the proliferating phase, MVD was 73.4 +/- 14.63 . In the involuting phase, MVD was 30.2 +/- 9.1 (P < 0.01). The correlation between the HIF-1alpha and VEGF was positive (P < 0.01). There was a positive correlation between the HIF-1alpha and MVD (P < 0.01).</p><p><b>CONCLUSIONS</b>There might be a special hypoxia microenvironment in endothelial cell of the hemangioma in proliferating phase , which could up-regulate the expression of the HIF-1alpha protein. The HIF-1alpha protein could also up-regulate the VEGF protein and then result in the angiogenesis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Vascular Endothelial Growth Factor A / Hypoxia-Inducible Factor 1, alpha Subunit / Hemangioma / Metabolism / Neoplasm Staging / Neovascularization, Pathologic Type of study: Prognostic study Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: Chinese Journal: Chinese Journal of Plastic Surgery Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Vascular Endothelial Growth Factor A / Hypoxia-Inducible Factor 1, alpha Subunit / Hemangioma / Metabolism / Neoplasm Staging / Neovascularization, Pathologic Type of study: Prognostic study Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: Chinese Journal: Chinese Journal of Plastic Surgery Year: 2005 Type: Article