Epidemiology, diagnosis and treatment of Middle East respiratory syndrome / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 443-450, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-255171
ABSTRACT
Middle East respiratory syndrome (MERS) has raised global public health concerns. The recent outbreak of MERS coronavirus (MERS-CoV) infection has led to 1 338 laboratory-confirmed cases in 26 countries worldwide as reported till 19 June, 2015. MERS-CoV may be considered a zoonotic virus that has crossed the species barrier to humans, but the pathogenesis and the routes of transmission are not completely understood. Most MERS-CoV cases reported thus far have a history of residence in or travel to the Middle East. Human-to-human transmission though was observed on some occasions in Korea, it is documented as non-sustainable event. The envelope spike glycoprotein on the surface of MERS-CoV which mediates receptor binding, membrane fusion and viral entry is thought to be involved in the mechanism of MERS-CoV.No specific and effective treatment for MERS-CoV is currently recommended, although supportive treatment has played an important role. Prophylactic strategies are necessary to prevent MERS-CoV infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Therapeutics
/
Virulence
/
Epidemiology
/
Coronavirus Infections
/
Diagnosis
/
Virus Internalization
/
Spike Glycoprotein, Coronavirus
/
Middle East Respiratory Syndrome Coronavirus
/
Metabolism
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2015
Type:
Article
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