Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 211-216, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-255209
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
Signal Transduction
/
Cadherins
/
Transforming Growth Factor beta
/
MicroRNAs
/
Epithelial-Mesenchymal Transition
/
Wnt Signaling Pathway
/
Neoplasm Metastasis
/
Neoplasm Recurrence, Local
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2015
Type:
Article
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