Progress on association between autophagy and cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 204-210, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-255210
ABSTRACT
Autophagy is an evolutionarily well conserved cellular catabolic process.Cellular proteins and organelles are engulfed to autophagosomes and eventually delivered to lysosomes for degradation. Autophagy is closely associated with a variety of human diseases especially cancer. At present, it has been widely accepted that autophagy is a "double-edged sword" in cancer it blocks tumorigenesis at the early stage, while it facilitates tumor development at the promotion and progression stage. Moreover, autophagy can be induced by chemotherapy and radiotherapy, which is generally play a pro-survival function. Thus, autophagy is an important target for cancer therapy, and suppression of autophagy to enhance the efficacy of cancer therapeutic agents is a novel strategy in cancer therapy under active clinical trials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Cell Transformation, Neoplastic
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2015
Type:
Article
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