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Cancer Stem Cells in Brain Tumors and Their Lineage Hierarchy
International Journal of Stem Cells ; : 12-15, 2012.
Article in English | WPRIM | ID: wpr-25527
ABSTRACT
Despite recent advances in the development of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. The chemo-resistance of this tumor is attributed to tumor heterogeneity. To explain this unique chemo- resistance, the concept of cancer stem cells has been evoked. Cancer stem cells, a subpopulation of whole tumor cells, are now regarded as candidate therapeutic targets. Here, the author reviews and discusses the cancer stem cell concept.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Neoplastic Stem Cells / Population Characteristics / Brain / Brain Neoplasms / Glioma Type of study: Prognostic study Language: English Journal: International Journal of Stem Cells Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Neoplastic Stem Cells / Population Characteristics / Brain / Brain Neoplasms / Glioma Type of study: Prognostic study Language: English Journal: International Journal of Stem Cells Year: 2012 Type: Article