Expressions of Her-2, EGFR, PS-2 and ER in breast cancer and their clinical implications / 南方医科大学学报
Journal of Southern Medical University
;
(12): 231-233, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-255346
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expressions of human epidermal growth factor receptor 2 (Her-2), epidermal growth factor receptor (EGFR), presenilin 2 (PS-2) and estrogen receptor (ER) in breast cancer and discuss their clinical implications.</p><p><b>METHODS</b>The expressions of Her-2, EGFR, PS-2 and ER were measured immunohistochemically in 108 patients with breast cancer.</p><p><b>RESULTS</b>The positive expression rates of Her-2, EGFR, PS-2 and ER were 37.0%, 40.7%, 57.4% and 53.7% respectively in the breast cancer patients. The expression of Her-2 was not correlated with EGFR, but inversely correlated with PS-2 and ER. The expressions of Her-2 and EGFR, PS-2, ER were correlated with the histological grades (P<0.05), and Her-2, EGFR and ER expressions with lymph node metastasis (P<0.05). The expressions of Her-2, EGFR, PS-2 and ER did not correlate to the pathological types, patient's age and tumor size (P>0.05).</p><p><b>CONCLUSION</b>Expressions of Her-2 and EGFR often suggests an unfavorable prognosis while expressions of PS-2 and ER suggest a more favorable one. Expressions of Her-2, EGFR, PS-2 and ER are useful prognostic factors in breast cancer patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Breast Neoplasms
/
Immunohistochemistry
/
Receptors, Estrogen
/
Biomarkers, Tumor
/
Carcinoma, Ductal, Breast
/
Receptor, ErbB-2
/
Presenilin-2
/
ErbB Receptors
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article
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