Relationship between mitochondrial DNA instability and interleukin-8 activity in gastric mucosa / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 35-37, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-255360
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between mitochondrial DNA instability (mtMSI) and interleukin-8 (IL-8) activity in gastric mucosa of various lesions.</p><p><b>METHODS</b>IL-8 level in gastric mucosa was assayed using ELISA method. The mtMSI was detected by PCR-SSCP techniques.</p><p><b>RESULTS</b>mtMSI was observed in 11 out of 30 (36.7%) gastric cancers, 2 of 15 (13.3%) intestinal metaplasia, 2 of 10 dysplasia and 1 of 10 chronic atrophic gastritis. IL-8 level in mtMSI+ group [(76.8 +/- 3.8) pg/mg] was significantly higher than that in mtMSI- group [(48.3 +/- 3.6) pg/mg, P < 0.05].</p><p><b>CONCLUSION</b>mtMSI closely correlates with IL-8 level in gastric mucosa and is involved in gastric carcinogenesis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Precancerous Conditions
/
Stomach Neoplasms
/
DNA, Mitochondrial
/
Enzyme-Linked Immunosorbent Assay
/
Polymerase Chain Reaction
/
Interleukin-8
/
Polymorphism, Single-Stranded Conformational
/
Genomic Instability
/
Gastric Mucosa
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2003
Type:
Article
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