Mutation of 5'noncoding region of the bcl-6 gene in diffuse large B cell lymphomas / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 10-13, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-255365
ABSTRACT
<p><b>OBJECTIVE</b>To observe the mutation of 5'noncoding region of bcl-6 gene in diffuse large B cell lymphoma (DLBCL) and its effect on lymphoma pathogenesis.</p><p><b>METHODS</b>38 DLBCL, 2 reactive hyperplasias, 5 follicular lymphomas and 5 T cell lymphomas were chosen for PCR direct sequence analysis using two sets of primers in 5'noncoding region of the bcl-6 gene.</p><p><b>RESULTS</b>No mutation was found in the marginal region of reactive hyperplasias, T cell lymphomas, and follicular lymphomas but detected in 1/2 of the follicular center cells, and 7/38 cases of DLBCL. The incidence is less than that seen in other reports. Basepairs substitution and point insertion were the main mutation types.</p><p><b>CONCLUSIONS</b>The positive rate of mutation of 5'noncoding region of bcl-6 gene in DLBCL is 18.7%, less frequent than the published data of DLBCL reported in other countries. It may, in some extent, participate in the pathogenesis and progression of DLBCL.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
China
/
Polymerase Chain Reaction
/
Lymphoma, B-Cell
/
Lymphoma, Large B-Cell, Diffuse
/
Proto-Oncogene Proteins
/
Point Mutation
/
5' Untranslated Regions
/
Asian People
/
DNA-Binding Proteins
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2003
Type:
Article
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