Research on the relationship between pathological features of the uveal melanoma and prognosis / 中华病理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the pathological features of uveal melanoma and to evaluate their influence on patients' prognosis.</p><p><b>METHODS</b>Paraffin embedded uveal melanoma tissues of 115 cases were examined using routine pathologic methods. Three histological types were classified according to the modified Callender system and patients were followed clinically. The data were done regression and survival analysis by SPSS statistic soft.</p><p><b>RESULTS</b>The patient with epithelial cell type, mixed type, and spindle cell type uveal melanoma have different life times, the average life time is 35.6 +/- 21.5 months, 63.7 +/- 37.0 months, 69.5 +/- 36.5 months in turn, patients with epithelial uveal melanoma had shorter survival time than other two types. The survival time was negatively related to the largest diameter of contact area with the sclera, the largest height and the depth of tumor invasion to the sclera.</p><p><b>CONCLUSIONS</b>Epithelial uveal melanoma is more malignant than the other two types. Histological classification of this tumor combined with other pathologic features can indicate the patient's prognosis.</p>