Primitive study of the cell lineage and Epstein-Barr virus infection in so called malignant histiocytosis with tissue microarray technique / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 497-501, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-255381
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cell lineage and Epstein-Barr virus infection in previously diagnosed cases of malignant histiocytosis (MH) with tissue microarray technique.</p><p><b>METHODS</b>Using tissue-chips, immunohistochemical staining, in situ hybridization and PCR to analyze 5 autopsy cases of MH.</p><p><b>RESULTS</b>(1) In all 5 cases, positive reactions of CD45RO, CD3 epsilon, TIA-1, Granzyme B were detected in the neoplastic cells, whereas negative reactions were found with CD30, CD20, CD56. (2) All cases revealed EBER1/2 positivity in neoplastic cells.</p><p><b>CONCLUSION</b>Previously diagnosed malignant histiocytosis is an EBV-associated aggressive NK/T cell lymphoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Virology
/
Immunohistochemistry
/
Polymerase Chain Reaction
/
Lymphoma, T-Cell
/
In Situ Hybridization
/
Epstein-Barr Virus Infections
/
Allergy and Immunology
/
Histiocytic Sarcoma
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2002
Type:
Article
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