A clinicopathological study of fifteen epithelioid angiosarcoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 407-410, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-255391
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathological features of epithelioid angiosarcoma (EA) and to propose its differential diagnosis.</p><p><b>METHODS</b>15 EAs were observed by means of HE staining, immunohistochemical staining (ABC method) and in part by electron microscopy.</p><p><b>RESULTS</b>Twelve cases occurred in men and three in women. Clinical symptoms included a focal mass with pain, weight loss and weakness. The tumors were located in the retroperitoneum (n = 3), extremities (n = 3), femur (n = 4), thyroid (n = 2), supraobit (n = 1), soft tissue of thorax (n = 1), soft tissue of neck (n = 1). Radiographic evaluation demonstrated solid to cystic neoplasms ranging from 3 to 20 cm in diameter. Histologically, the epithelioid cells were arranged diffusely or in nests with hemorrhage and focal necrosis. Atypical tumor cells lined the irregular spaces and single or small nests of cells grouped around a lumen containing red blood cells. FVIII, CD34, CD31,CK and EMA were positive in tumor cells and SMA was positive in pericytes. Ultrastructurally, intracytoplasmic vacuoles, Weibel-Palades, intermediate filaments and basal lamina could be seen. Surgical resection was the treatment of choice, occasionally with adjuvant chemotherapy. Follow-up. Two patients are presently alive 19 months and 7 years following diagnosis. Twelve died from 2 weeks to 38 months with a median interval of 19 months after lumpectomy. One patient was lost to follow up. There were 8 cases which had metastases to lungs, bones, lymph nodes and abdominal cavity.</p><p><b>CONCLUSIONS</b>EA is a high-grade sarcoma. Endothelial derivation can be confirmed by immunohistochemical staining and ultrastructural findings. The differential diagnosis of EA includes metastatic carcinoma, epithelioid hemangioendothelioma, melanoma, epithelioid sarcoma etc.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Sarcoma
/
Immunohistochemistry
/
Epithelioid Cells
/
Hemangioendothelioma, Epithelioid
/
Diagnosis
/
Diagnosis, Differential
/
Melanoma
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2002
Type:
Article
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