The expressions of TGF-beta1 and Smad 2 mRNA on diseased glomeruli and their significance in the development of glomerulosclerosis / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 314-317, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-255425
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expressions of transforming growth factor-beta1 (TGF-beta1) and its signaling transduction molecule Smad 2 and their significance in the development of glomerulosclerosis.</p><p><b>METHODS</b>Using in situ hybridization and immunohistochemistry to detect Smad 2 mRNA expression and TGF-beta1, collagen IV, fibronectin expression in renal biopsies from 61 cases with a spectrum of glomerulonephritis including IgA nephropathy (40 cases), membranous glomerulonephritis (10 cases) and sclerosing glomerulonephritis (11 cases), compared with 11 cases of glomerular mild lesion with image analysis system.</p><p><b>RESULTS</b>With the exception of Smad 2 mRNA expression in mild type IgA nephropathy, all other types of diseased glomeruli showed increased expression of both TGF-beta1 and Smad 2 mRNA when compared with the 11 cases of mild glomerular lesions. The expressions of glomerular TGF-beta1 and Smad 2 mRNA positively correlated with collagen IV and fibronectin deposition in the glomeruli.</p><p><b>CONCLUSIONS</b>TGF-beta1 and Smad 2 may be involved in the excessive deposition of glomerular extracellular matrix and play an important role in the development of glomerulosclerosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Immunohistochemistry
/
Trans-Activators
/
Chemistry
/
Transforming Growth Factor beta
/
Fibronectins
/
Collagen Type IV
/
DNA-Binding Proteins
/
Smad2 Protein
/
Transforming Growth Factor beta1
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2002
Type:
Article
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