Clinicopathological and biological features of breast cancer in young females and their relationship with prognosis / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 284-288, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-255663
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between clinicopathological and biological characteristics and prognosis in young females with breast cancer.</p><p><b>METHODS</b>The clinicopathological data of 99 young patients (< or =35years) with primary breast cancer were analyzed retrospectively. All the 99 patients were followed up for 5 years. The histological specimens were reviewed. The expression of ER, PR, AR, c-erbB2, ki67, p53 and BRCA1 were assessed by immunohistochemistry in 63 carcinomas.</p><p><b>RESULTS</b>The lymph node involvement, 5-year metastasis and 5-year survival rate were 59.6% (59/99), 28.0% (26/ 93) and 72.7% (72/99), respectively. The univariate analysis showed that the survival was related to lymphatic vessel invasion, fat involvement, node-positive status, EIC, AR and c-erbB2 expression. The COX multivariate analysis identified that only node-positive status, AR negativity and c-erbB2 overexpression were independent prognostic factors.</p><p><b>CONCLUSION</b>Our data demonstrated that the lymph node status and c-erbB2 expression are strong prognostic factors in young patients with breast cancer. AR may be an adjuvant prognostic factor. The therapeutic measurement could not benefit the outcome radically.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Breast Neoplasms
/
Immunohistochemistry
/
Receptors, Androgen
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Biomarkers, Tumor
/
Proportional Hazards Models
/
Survival Analysis
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2007
Type:
Article
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