Treatment and prognosis of low-grade malignant endometrial stromal sarcoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 74-78, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-255719
ABSTRACT
<p><b>OBJECTIVE</b>To review the experience in the treatment of low-grade malignant endometrial stromal sarcoma.</p><p><b>METHODS</b>The data of 41 patients with low-grade malignant endometrial stromal sarcoma surgically treated between 1982 and 2004 were reviewed. Statistical analysis was carried out using chi(2) and Kaplan-Meier life table.</p><p><b>RESULTS</b>Of these 41 patients, 24 suffered from irregular vaginal bleeding, and 30 had been diagnosed to have leiomyoma before treatment. Thirty patients but 11 underwent surgical management with uterus removed. Thirty-three patients received postoperative adjuvant therapy including radiation and/or chemotherapy. The 5-year and 10-year actuarial survival was 87. 5% and 77. 8%, respectively. Eighteen patients (43. 9%) developed recurrent disease, most of which in the pelvis. The mean time to recurrence was 31 months (range 6 to 78 months) with the median time of 26 months. The recurrent rate was 66.7% for patients whose ovarian function was reserved versus 37. 5% for those without reservation. Patients who received adjuvant therapy had a lower recurrent rate (30. 3%) than those who did not (87. 5%). The recurrent rate of the patients treated with postoperative adjuvant radiation was 32. 3% (10/31) versus 80% (8/10) for those patients without. The 5-year actuarial survival rate of patients with recurrent disease was 71. 8%.</p><p><b>CONCLUSION</b>Low-grade malignant endometrial stromal sarcoma has a good prognoses though dwarfed by higher late recurrence after initial treatment. Postoperative adjuvant radiation is helpful to reduce local recurrence. Endometrial stromal sarcoma;</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Therapeutics
/
Brachytherapy
/
Antineoplastic Combined Chemotherapy Protocols
/
Cesium Radioisotopes
/
Retrospective Studies
/
Follow-Up Studies
/
Endometrial Neoplasms
/
Chemotherapy, Adjuvant
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2007
Type:
Article
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