Association between smoking, pancreatic insulin secretion and insulin resistance in Chinese subjects with or without glucose intolerance / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2233-2237, 2007.
Article
in English
| WPRIM
| ID: wpr-255806
ABSTRACT
<p><b>BACKGROUND</b>There are studies suggesting smoking may increase the risk of type 2 diabetes. Effects of smoking on insulin secretion and insulin resistance (IR) are, however, controversial.</p><p><b>METHODS</b>This is a cross-sectional study. Since there were very few smokers among Hong Kong Chinese women, only men (n = 1068) were analyzed in this report. Fasting and 2-hour plasma glucose and insulin were measured. Insulinogenic index as well as beta-cell function and IR based on homeostatic model assessment (HOMA) by computer model (HOMA Calculator v2.2) were calculated.</p><p><b>RESULTS</b>Of the 1068 men, 147 had newly diagnosed diabetes, 131 newly diagnosed impaired glucose tolerance (IGT) and 790 were non-diabetic normal controls. Smokers had similar fasting and 2-hour insulin levels, insulinogenic index and HOMA derived beta-cell function as compared to non-smokers in the groups with diabetes, IGT or normal oral glucose tolerance test (OGTT). IR was also similar between smokers, ex-smokers and non-smokers in those with normal OGTT. In men with IGT or diabetes, after adjustment for age and body mass index, smokers were more insulin resistant as compared to non-smokers (IR, IGT 1.59 +/- 1.07 vs 1.03 +/- 0.54, P < 0.05; diabetes 1.96 +/- 1.36 vs 1.06 +/- 0.45, P < 0.01). With Logistic regression analysis, comparing smokers and non-smokers, IR was independently associated with smoking (odds ratio (95% CI), IGT 2.23 (1.05, 4.71); diabetes 3.92 (1.22, 12.58)). None of the other insulin parameters enter into the model among those with normal OGTT or comparing ex-smokers and non-smoker or smokers and ex-smokers.</p><p><b>CONCLUSIONS</b>In Chinese men, smoking did not show any direct association with insulin levels and pancreatic insulin secretion. Smoking men with IGT or diabetes appeared more insulin resistant than their non-smoking counterparts.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Insulin Resistance
/
Smoking
/
Glucose Intolerance
/
Bodily Secretions
/
Insulin-Secreting Cells
/
Insulin
/
Metabolism
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2007
Type:
Article
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