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Detection of CCAAT/enhancer binding protein alpha gene mutations in acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology ; (12): 299-302, 2005.
Article in Chinese | WPRIM | ID: wpr-255886
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between CCAAT/enhancer binding protein alpha (C/EBPalpha) gene mutations and the development of acute myeloid leukemia (AML).</p><p><b>METHODS</b>The whole coding region of C/EBPalpha gene were screened in 48 cases of AML and 11 normal subjects by PCR-single strand conformation polymorphism (PCR-SSCP) and sequencing.</p><p><b>RESULTS</b>C/EBPalpha mutations were detected in 5 of 48 AML patients. Four duplications and 1 deletion were confirmed by DNA sequencing. All of those are newly identified mutations.</p><p><b>CONCLUSIONS</b>Different mutation types of C/EBPalpha gene exist in a small number of patients with AML and might be related to the pathogenesis of some leukemias.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukemia, Myeloid, Acute / CCAAT-Enhancer-Binding Protein-alpha / Genetics / Mutation Type of study: Diagnostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hematology Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukemia, Myeloid, Acute / CCAAT-Enhancer-Binding Protein-alpha / Genetics / Mutation Type of study: Diagnostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hematology Year: 2005 Type: Article