The expression of α2A-adrenoceptors in the calcium-binding protein immunoreactive interneurons in rat prefrontal cortex / 生理学报
Acta Physiologica Sinica
;
(6): 537-544, 2014.
Article
in English
| WPRIM
| ID: wpr-256004
ABSTRACT
The α2A adrenoceptors (α2A-ARs) are the most common adrenergic receptor subtype found in the prefrontal cortex (PFC). It is generally accepted that stimulation of postsynaptic α2A-ARs on pyramidal neurons are key to PFC functions, such as working memory. However, the expression of α2A-ARs in interneurons is largely unknown. In the present study using double-labeling immunofluorencence technique, we investigated the expression of α2A-ARs in major types of rat PFC interneurons expressing calcium-binding proteins parvalbumin (PV), calretinin (CR), and calbindin (CB). Our data demonstrated that α2A-ARs are highly expressed in calcium-binding protein immunoreactive interneurons of rat PFC, suggesting that stimulation of α2A-ARs may alter neural networks comprising pyramidal neurons and interneurons, thereby exerting a beneficial effect on PFC cognitive functions. The present study provides the morphological basis for a potential mechanism by which stimulation of α2A-ARs induces cognitive improvement.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parvalbumins
/
Prefrontal Cortex
/
Receptors, Adrenergic, alpha-2
/
Cell Biology
/
Calbindins
/
Calbindin 2
/
Interneurons
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2014
Type:
Article
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