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Modification of Chinese hamster ovary cells / 生物工程学报
Chinese Journal of Biotechnology ; (12): 415-419, 2002.
Article in Chinese | WPRIM | ID: wpr-256193
ABSTRACT
Chinese hamster ovary cells (CHO) are preferable to prokaryotic, yeast or insect cells as hosts for biopharmaceutical production due to the products are more similar to their natural conformation. However, CHO cells confront tremendous difficulties when cultured in large scale such as mal-adaptation to serum-free medium, apoptosis and over-growth without limitation. So in addition to optimizing CHO system in respect of medium, environment and expression vector, modification of CHO cells themselves has drawn more and more attention. Here the main progress in CHO-modification is reviewed.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Transfection / Cell Cycle / Cell Division / CHO Cells / Apoptosis / Cell Cycle Proteins / Genetic Vectors / Genetics / Metabolism Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Transfection / Cell Cycle / Cell Division / CHO Cells / Apoptosis / Cell Cycle Proteins / Genetic Vectors / Genetics / Metabolism Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2002 Type: Article