Circadian Effects on Neural Blockade of Intrathecal Hyperbaric Bupivacaine
The Korean Journal of Pain
;
: 186-189, 2010.
Article
in English
| WPRIM
| ID: wpr-25623
ABSTRACT
BACKGROUND:
Circadian variations in the absorption, distribution, protein binding, elimination and metabolism of drugs account for many of the administration-time-dependent differences in their pharmacokinetics. The aim of this study is to determine whether the time of intrathecal injection influences spinal anesthesia.METHODS:
Ninety patients scheduled for orthopedic surgery were randomly assigned to three groups. Each group received spinal anesthesia with 0.5% bupivacaine 10 mg at different times; group AM (8 am to 1200), group Noon (1200 to 400 pm) and group PM (400 pm to 800 pm). Sensory and motor blockade were assessed by pinprick and a four-point modified Bromage scale. Time to first postoperative analgesic requirement and side effects such as hypotension, bradycardia, nausea, and shivering were recorded.RESULTS:
No significant differences were found among the three groups in peak sensory blockade, duration of motor block to Bromage 1 or side effects, but time to first postoperative analgesic requirement (P = 0.008), and recovery time of S1 sensation to pinprick were significantly prolonged in group Noon compared with the other groups (P = 0.03).CONCLUSIONS:
The tine of administration of spinal local anesthetics influences the duration of local anesthesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthopedics
/
Protein Binding
/
Sensation
/
Shivering
/
Injections, Spinal
/
Bradycardia
/
Bupivacaine
/
Absorption
/
Hypotension
/
Anesthesia, Local
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Pain
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS