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Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm
Gut and Liver ; : 228-236, 2016.
Article in English | WPRIM | ID: wpr-25626
ABSTRACT
BACKGROUND/

AIMS:

To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm.

METHODS:

We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms.

RESULTS:

A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 high-grade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sex-matched patients without metachronous gastric neoplasms (p=0.020).

CONCLUSIONS:

In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Proportional Hazards Models / Incidence / Multivariate Analysis / Risk Factors / Genes, mos / Neoplasms, Second Primary / Genes, APC / Thrombomodulin / DNA Methylation Type of study: Etiology study / Incidence study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Proportional Hazards Models / Incidence / Multivariate Analysis / Risk Factors / Genes, mos / Neoplasms, Second Primary / Genes, APC / Thrombomodulin / DNA Methylation Type of study: Etiology study / Incidence study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2016 Type: Article