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Experimental study on antivirus activity of traditional Chinese medicine / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 452-455, 2004.
Article in Chinese | WPRIM | ID: wpr-256328
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the difference of anticytomegaloviral activity of three kinds of traditional Chinese medicines which are the injections of Jinye Baidu, Radix Isatidis and Indigowoa in vitro.</p><p><b>METHOD</b>The inhibitory activity of three traditional Chinese medicines against human cytomeglovirus (HCMV AD169) infected human embryo lung fibroblasts (HELF) was observed by cytopathic effect method (CPE) and MTT method in vitro. According their value of A, anticytomegaloviral activity has evaluated.</p><p><b>RESULT</b>Experimental study in vitro showed that the 50% toxicity dose (TD50) of Jinye Detoxifying, Radix Isatidis root and Indigowoa were 20, 10.23, 20.23 g x L(-1) respectively; the 50% inhibitory concertration (IC50) were 5.65, 3, 5.71 g x L(-1) respectively; the therapeutic index (TI) were 3.54, 3.41 and 3.54 respectively. It suggested that three traditional Chinese medicines had anticytomeglovirus activity and their effect increased with their concentration.</p><p><b>CONCLUSION</b>Three traditional Chinese medicines of the parenteral solution of Jinye Detoxifying, Radix Isatidis root and Indigowoa have antiviral activity when they are diluted in 1200. They are safe and valuable drug for inhibiting cytomeglovirus infection.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Pharmacology / Plants, Medicinal / Virology / Drugs, Chinese Herbal / Cells, Cultured / Chemistry / Plant Roots / Plant Leaves / Inhibitory Concentration 50 Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Pharmacology / Plants, Medicinal / Virology / Drugs, Chinese Herbal / Cells, Cultured / Chemistry / Plant Roots / Plant Leaves / Inhibitory Concentration 50 Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2004 Type: Article