Screening of angiotensin converting enzyme inhibitors from Salvia miltiorrhizae / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 359-362, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-256353
ABSTRACT
<p><b>OBJECTIVE</b>To screen angiotensin converting enzyme inhibitor (ACEI) from traditional Chinese medicine, Salvia miltiorrhiza.</p><p><b>METHOD</b>Hydrophilic and lipophilic fractions of S. miltiorrhiza were isolated, and their effective components were screened by a fluorimetric assay for inhibition of angiotensin converting enzyme (ACE).</p><p><b>RESULT</b>Water-soluble fractions, total salvianolic acids and salvianolic acid B markedly decreased ACE activity of rabbit lung tissue. Their IC50 value were (2.45 +/- 0.07), (0.24 +/- 0.02), (0.02 +/- 0.01) g x L(-1) respectively. Lipophilic components or phenanthraquinones including tanshinone I and II showed no changes on the activity of ACE.</p><p><b>CONCLUSION</b>S. miltiorrhiza inhibits angiotensin converting enzyme and its active components are in aqueous extract, in which the main were salvianolic acids including salvianolic acids B.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Benzofurans
/
In Vitro Techniques
/
Angiotensin-Converting Enzyme Inhibitors
/
Drugs, Chinese Herbal
/
Chemistry
/
Peptidyl-Dipeptidase A
/
Plant Roots
/
Salvia miltiorrhiza
Type of study:
Diagnostic study
/
Screening study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2004
Type:
Article
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