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Effect of osteopractic total flavone on bone mineral density and bone histomorphometry in ovariectomized rats / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-256358
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of osteopractic total flavone on bone histomorphometry of osteoporosis model in rath with ovariectomized female rat models.</p><p><b>METHOD</b>The ovariectomy-induced model, bone sliceswith calcium, pigmentation, and Leica Qwin image analysis system were adopted on bone histomorphometry.</p><p><b>RESULT</b>As compared with the model group, the effect of small-dose group and middle-dose group of osteopractic total flavone on TBV% of shankbone increased significantly; the effect of small-dose group and middle-dose group of osteopractic total flavone on TRS% of shankbone reduced significantly and TFS%, AFS%, MAR, BFR of shankbone reduced obviously; the effect of middle-dose group of osteopractic total flavone on OSW and mAR reduced obviously, the effect of small-dose group of osteopractic total flavone on them had the tendency of reducing, but there was no statistical significance.</p><p><b>CONCLUSION</b>The ovariectomized rats having been fed with osteopractic total flavone for 6 months, TBV% increased significantly while TRS%, AFS%, MAR, BFR, OSW, and mAR reduced obviously. It indicates that the therapeutical effect of osteopractic total flavone on ovariectomy-induced osteoporosis model is significant. And the ovariectomy-induced osteoporosis model is a high transformative type of osteoporosis model in which bone absorption is higher than bone formation.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoporosis / Pathology / Pharmacology / Rats / Female / Drugs, Chinese Herbal / Ovariectomy / Bone Density / Chemistry / Rats, Wistar Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoporosis / Pathology / Pharmacology / Rats / Female / Drugs, Chinese Herbal / Ovariectomy / Bone Density / Chemistry / Rats, Wistar Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2004 Type: Article