Influence of sargassum fusiforme polysaccharide on apoptosis of tumor cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 245-247, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-256379
ABSTRACT
<p><b>OBJECTIVE</b>To study mechanism of antitumor activity of Sargassum Fusiforme Polysaccharide (SFPS).</p><p><b>METHOD</b>The effect on cell cycle and apoptosis was studied with flow cytometry (FCM). Intracellular calcium concentration [Ca2+]i was marked with Fluo-3/AM and measured with laser scanner confocal microscope (LSCM).</p><p><b>RESULT</b>SFPS inhibited G0/G1 stage SGC-7901 from entering to S stage and increased APO%. The [Ca2+]i showed a transient rise and return to the original level. The concentration could be raised again by administering CaCl2.</p><p><b>CONCLUSION</b>The antitumor effect of SFPS seems to be accomplished through the apoptosis associated with the increase in intracellular calcium concentration. Intracellular stores release the calcium during its action.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Polysaccharides
/
Stomach Neoplasms
/
Calcium Chloride
/
Tumor Cells, Cultured
/
Cell Cycle
/
Chemistry
/
Calcium
/
Apoptosis
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2004
Type:
Article
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