A research of endothelial cell-targeted therapy for cure of hypertrophic scar / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 254-257, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-256438
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the feasibility of endothelial cell-targeted therapy to cure post-burn hypertrophic scar.</p><p><b>METHODS</b>A hypertrophic scar animal model was made. Intralesional injecting of VEGF monoclonal antibody was performed for three weeks. The changes of scar in volume and morphology were observed.</p><p><b>RESULTS</b>1. The volume of scar decreased. 2. The number of the capillary, the amount of collagen I and collagen III decreased. 3. Transmission electron microscope examinations demonstrated many dead or apoptotic fibroblasts and endothelial cells. Fibrocytes were seen relatively common.</p><p><b>CONCLUSION</b>VEGF induces the growth and development of hypertrophic scar in that it induces excessive and uncontrollable angiogenesis, which favors excessive collagen synthesis. Endothelial cell-targeted therapy may be a promising method to cure post-burn hypertrophic scar.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Burns
/
Feasibility Studies
/
Cicatrix, Hypertrophic
/
Apoptosis
/
Collagen Type I
/
Collagen Type III
/
Endothelial Cells
/
Vascular Endothelial Growth Factor A
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2003
Type:
Article
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