Expression of cancerous inhibitor of protein phosphatase 2A in tissue microarray of colorectal cancer and its clinical significance / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 1102-1106, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-256852
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis.</p><p><b>METHODS</b>CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.</p><p><b>RESULTS</b>Up-regulated CIP2A expression was closely related with TNM staging, histological type, peritoneal seeding and liver metastasis (all P<0.05), but not related with gender, age, tumor location, CEA, family history and grade of differentiation. Overall survival rates of 1-, 3-, 5-, and 10-year in high CIP2A expression group were 97.1%, 71.4%, 59.2%, and 44.4% respectively, significantly lower than 98.2%, 85.7%, 80.3%, and 74.9% in low CIP2A expression group(P=0.021). Multivariate analysis showed that CIP2A was not an independent factor associated with prognosis(P=0.099, HR=1.982, 95%CI0.879 to 4.469).</p><p><b>CONCLUSIONS</b>Up-regulated CIP2A expression is closely related to clinicopathology of colorectal cancer. CIP2A may be used as a potential predictive marker of metastasis, prognosis and therapeutic target in colorectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Autoantigens
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Biomarkers, Tumor
/
Survival Rate
/
Tissue Array Analysis
/
Protein Phosphatase 2
/
Liver Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2013
Type:
Article
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