Meta-analysis of dapoxetine on demand in the treatment of premature ejaculation / 中华男科学杂志
National Journal of Andrology
;
(12): 930-935, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-256980
ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy of dapoxetine on demand for premature ejaculation and provide evidence for clinical decision-making.</p><p><b>METHODS</b>We searched PubMed, Embase, BIOSIS Previews, Cochrane Library, CNKI Database and Wanfang Database for literature on dapoxetine on demand for premature ejaculation. We performed meta-analysis on the identified publications and evaluated its therapeutic efficacy based on the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGI), and composite PRO criteria for clinical benefit (CCCB).</p><p><b>RESULTS</b>Four relevant studies were included involving 6 081 cases of premature ejaculation. Compared with the placebo controls, the patients treated with dapoxetine on demand showed significant improvement in IELT (WMD = 1.39, 95% CI [1.23, 1.55], P < 0.000 01), PGI (OR = 2.59, 95% CI [2.21, 3.04], P < 0. 000 01), and CCCB (OR = 2.59, 95% CI [1.98, 3.39], P < 0.000 01). There were significant differences between the 60 mg and 30 mg dapoxetine groups in IELT (WMD = 0.46, 95% CI [0.19, 0.74], P = 0.001 0) and PGI (OR = 1.32, 95% CI [1.06, 1.64], P = 0.01), but not in CCCB (OR = 1.39, 95% CI [0.90, 2.15], P = 0.13).</p><p><b>CONCLUSION</b>Dapoxetine on demand can prolong IELT and improve PGI and CCCB, either at the dose of 60 mg or 30 mg, and has an even better efficacy in prolonging IELT and improving PGI at 60 mg.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Benzylamines
/
Treatment Outcome
/
Therapeutic Uses
/
Drug Therapy
/
Ejaculation
/
Premature Ejaculation
/
Naphthalenes
Type of study:
Controlled clinical trial
/
Prognostic study
/
Systematic reviews
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2012
Type:
Article
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