Sperm DNA damage and sperm-nucleoprotein transition correlate to acrosin activity and seminal parameters / 中华男科学杂志
National Journal of Andrology
;
(12): 925-929, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-256981
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters.</p><p><b>METHODS</b>We collected 535 semen samples, assessed sperm DNA damage by sperm chromatin dispersion test, and analyzed the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters according to the WHO criteria.</p><p><b>RESULTS</b>Statistically significant differences were observed in sperm DNA damage among sperm-nucleoprotein transition, acrosin activity, sperm concentration and the percentage of grade a + b sperm (P < 0.01). Sperm DNA damage was positively correlated with age, sperm-nucleoprotein transition, sperm concentration and the percentage of grade d sperm (P < 0.01 or P < 0.05), but negatively correlated with acrosin activity (P < 0.001). Stepwise linear regression analysis demonstrated that age, sperm concentration, the percentage of grade d sperm, sperm-nucleoprotein transition and acrosin activity were independent variables related to the DNA fragmentation index (DFI). The abnormality rates of sperm-nucleoprotein transition, acrosin activity, sperm concentration and graded a + b sperm were significantly higher in the sperm DNA damage group (DFI > or = 30%) than in the normal control (DFI < 30%) (P < 0.01).</p><p><b>CONCLUSION</b>Sperm DNA damage is closely related with sperm-nucleoprotein transition, acrosin activity and seminal parameters, which may become another important independent parameter for the evaluation of sperm quality.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sperm Count
/
Sperm Motility
/
Spermatozoa
/
DNA Damage
/
Acrosin
/
Chromatin
/
DNA Fragmentation
/
Genetics
/
Infertility, Male
/
Metabolism
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2012
Type:
Article
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