Inhibitory effect of propentofylline on chronic prostatitis pain in rats and its mechanism / 中华男科学杂志
National Journal of Andrology
;
(12): 991-993, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-257004
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of propentofylline on the expressions of glial fibrillary acidic protein (GFAP) and TNF-alpha and its action mechanism in the rat model of chronic prostatitis pain (CPP).</p><p><b>METHODS</b>We equally randomized 30 male SD rats to groups A (sham operation), B (CPP model) and C (propentofylline intervention). After modelling, the rats in group C received intraperitoneal injection of propentofylline at 2 mg/kg, while those in groups A and B were injected intrathecally with the same dose of normal saline. At 15 days after the treatment, we examined the expressions of GFAP in the spinal cord and TNF-alpha in the prostate by immunohistochemistry.</p><p><b>RESULTS</b>The levels of GFAP and TNF-alpha were obviously lower in group A (2.56 +/- 0.16 and 1.34 +/- 0.05) than in B (16.79 +/- 0.72 and 3.46 +/- 0.05) and C (8.83 +/- 0.63 and 2.25 +/- 0.05), significantly increased in B as compared with A (P < 0.05). And the increase was markedly less in group C than in B (P < 0.05).</p><p><b>CONCLUSION</b>Propentofylline inhibits chronic prostatitis pain in the rat model by suppressing the activation of astroglia and the release of inflammatory mediators.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Prostatitis
/
Spinal Cord
/
Xanthines
/
Astrocytes
/
Chronic Disease
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2012
Type:
Article
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