Your browser doesn't support javascript.
loading
The synthesis of purine derivatives and its inhibitory activity on CD38 NADase / 药学学报
Acta Pharmaceutica Sinica ; (12): 1013-1020, 2015.
Article in Chinese | WPRIM | ID: wpr-257033
ABSTRACT
CD38 is a multifunctional enzyme expressed in a variety of mammalian tissues, its catalytic activity was involved in a wide range of physiological processes. Based on the reported inhibitor of human CD38 NADase, 33 purine derivatives were designed and synthesized. The biological activity assay showed that compounds 20 and 38 exhibited almost the same extent of inhibitory activities on human CD38 NADase as the lead compound H2. The results also revealed that small substituents at C-6 of purine ring gave no obvious effect on inhibitory activity, but phenylpropionyl moiety at N-2 could affect the binding mode of the compound with CD38. This study provides a reliable basis for future rational design of inhibitors for CD38.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Purines / Chemistry / Enzyme Inhibitors / ADP-ribosyl Cyclase 1 Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Purines / Chemistry / Enzyme Inhibitors / ADP-ribosyl Cyclase 1 Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article