Pain of high-throughput screening--pan assay interference compounds / 药学学报
Acta Pharmaceutica Sinica
;
(12): 925-930, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-257045
ABSTRACT
High-throughput screening is a regular approach available for identitying new lead compounds for the growing validated drug targets in drug screening. However, it has also introduced a large number of peculiar molecules which interfere drug screening. Pan assay interference compounds (PAINS) interfere with the progress of drug screening in various ways, such as interfering with a biochemical assay, modifying the protein, aggregate-based inhibitors and so on. So it is of vital significance to remove them. This paper has consulted the concept, category of PAINS and reviewed the way of PAINS interfering and the countermeasures to cope with them to direct the approach of high through screening and improve the hits percent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Discovery
/
High-Throughput Screening Assays
/
Methods
Type of study:
Diagnostic study
/
Screening study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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