The mechanism of action of valsartan studied by HPLC-TOF/MS / 药学学报
Acta Pharmaceutica Sinica
;
(12): 875-881, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-257053
ABSTRACT
High performance liquid chromatography-time-off-flight mass spectrometer (HPLC-TOFMS) technology coupled with partial least squares discriminant analysis (PLS-DA) processed by SIMCA-P software was applied to investigate serum endogenous metabolites alternations of valsartan in spontaneous hypertension rats (SHR). And MetPA platform was used to connect identified potential biomarkers in corresponding metabolic pathways to find possible therapeutic mechanism of valsartan. Valsartan significantly declined the blood pressure of SHRs (P < 0.05) at fourth week. The metabolic profiling significantly changed and four metabolites involved in G protein-coupled pathway were identified. Metabolomics is able to detect holistic and microcosmic alternations in organism, so as to elucidate therapeutic mechanism of drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Rats, Inbred SHR
/
Mass Spectrometry
/
Blood
/
Blood Pressure
/
Biomarkers
/
Discriminant Analysis
/
Least-Squares Analysis
/
Chromatography, High Pressure Liquid
/
Metabolome
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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