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The action mechanisms of Morus alba leaves extract for the treatment of diabetes based on plasma metabolomics / 药学学报
Acta Pharmaceutica Sinica ; (12): 830-835, 2015.
Article in Chinese | WPRIM | ID: wpr-257060
ABSTRACT
In order to evaluate the effect and mechanism of the mulberry leaf alkaloid, flavones, and polysaccharide intervention on diabetes, the overall metabolite profiling characteristics for the plasma of diabetic mouse was performed by using an ultra-performance liquid chromatography/electrospray-tandem mass spectrometry (UPLC-ESI-MS). The 8 potential biomarkers were found in diabetic mice plasma based on the data of MS/MS characteristics obtained from the UPLC-OrbitrapMS analysis, which mainly involved in sphingolipids, amino acid metabolic pathway. The principal component analysis showed that the normal group and model group were obviously distinguished and implied that metabolic disturbance was happened in diabetic mice plasma. The extracts of mulberry leaf flavonoids, polysaccharide, alkaloid had exhibited the effects of callback function for diabetic mice through regulating the amino acid metabolism and sphingolipid metabolism.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sphingolipids / Flavonoids / Blood / Biomarkers / Chemistry / Chromatography, High Pressure Liquid / Plant Leaves / Morus / Flavones / Diabetes Mellitus, Experimental Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sphingolipids / Flavonoids / Blood / Biomarkers / Chemistry / Chromatography, High Pressure Liquid / Plant Leaves / Morus / Flavones / Diabetes Mellitus, Experimental Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article