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Chemical comparison of different Farfarae Flos by NMR-based metabolomic approaches / 药学学报
Acta Pharmaceutica Sinica ; (12): 599-604, 2015.
Article in Chinese | WPRIM | ID: wpr-257094
ABSTRACT
1H NMR-based metabolomic approach combined with multivariate statistical analysis was used to evaluate the quality of 21 Farfarae Flos (FF) samples from different growth regions. Principal component analysis showed that wild and cultivated FF could be separated clearly, suggesting a big chemical difference existed between them. Supervised PLS-DA analysis indicated that the wild samples showed higher levels of secondary metabolites, such as bauer-7-ene-3β, 16α-diol, chlorogenic acid, rutin, 7-(3'-ethylcrotonoyloxy)-1α-(2'-methyl-butyryloxy)-3, 14-dehydro-Z-notonipetranone (EMDNT), tussilagone, β-sitosterol and sitosterone. This is consistent with traditional experience that the quality of wild samples are better than that of cultivated ones. The content of pyrrolizidine alkaloids senkirkine also differed greatly among samples from different habitats. The Pearson correlation analysis showed that senkirkine is positively correlated with 4, 5-O-dicaffeoylquinic acid, 3,5-O-dicaffeoylquinic acid, 3,4-O-dicaffeoylquinic acid, rutin, kampferol analogues, to a statistically significant extent. The correlation between the toxic compounds and the bioactive components in FF should be further studied.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Quinic Acid / Rutin / Sitosterols / Drugs, Chinese Herbal / Magnetic Resonance Imaging / Magnetic Resonance Spectroscopy / Chemistry / Chlorogenic Acid / Tussilago / Flowers Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quinic Acid / Rutin / Sitosterols / Drugs, Chinese Herbal / Magnetic Resonance Imaging / Magnetic Resonance Spectroscopy / Chemistry / Chlorogenic Acid / Tussilago / Flowers Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article