Chemical constituents from Morus notabilis and their cytotoxic effect / 药学学报
Acta Pharmaceutica Sinica
;
(12): 579-582, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-257098
ABSTRACT
Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Terpenes
/
Benzofurans
/
Flavonoids
/
Plant Extracts
/
Chemistry
/
Inhibitory Concentration 50
/
Morus
/
Hep G2 Cells
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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