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Radiosynthesis and preliminary evaluation of 5-(11Cmethyloxy)-L-tryptophan as PET tumor imaging / 药学学报
Acta Pharmaceutica Sinica ; (12): 565-568, 2015.
Article in Chinese | WPRIM | ID: wpr-257101
ABSTRACT
The PET tracer 5-([11C]methyloxy)-L-tryptophan (5-(11)CMTP) was prepared by nucleophilic fluorination and alkylation reaction via a two-step procedure in order to develop specific tumor probe. The biodistribution and microPET imaging of 5-(11)CMTP were executed. The results unveiled that the overall radiochemical yield with no decay correction was (14.6 ±7.2) %, the radiochemical purity was more than 95% and high uptake and long retention time of 5-(11)CMTP in liver, kidney and blood were observed but low uptake in brain and muscle were found, furthermore, high uptake of 5-(11)CMTP in tumor tissue was observed. It seems that 5-(11)CMTP will be a potential amino acid tracer for tumors imaging with PET.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Radioactive Tracers / Tryptophan / Diagnostic Imaging / Tissue Distribution / Positron-Emission Tomography / Amino Acids / Neoplasms Type of study: Diagnostic study Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radioactive Tracers / Tryptophan / Diagnostic Imaging / Tissue Distribution / Positron-Emission Tomography / Amino Acids / Neoplasms Type of study: Diagnostic study Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2015 Type: Article