Effects of tea polyphenols and tea pigments on cell cycle regulators in rat liver precancerous lesions / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 225-228, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-257261
ABSTRACT
<p><b>OBJECTIVES</b>This study is to investigate the effects of tea polyphenols and tea pigments on cell cycle regulators in rat liver precancerous lesions.</p><p><b>METHODS</b>The modified Solt-Farber precancerous liver rat model was used. Rats were given water, tea polypheol solution (0.1%) or tea pigment solution (0.1%) throughout the whole experiment (56 days). Cyclin D1, P21(WAF1/CIP1), GADD45 and PCNA protein expression were detected by Western blotting and the RT-PCR method was applied to study the expression of Cdk4.</p><p><b>RESULTS</b>Cyclin D1, Cdk4 and PCNA expressions were significantly inhibited, and the expression of P21(WAF1/CIP1) and GADD45 were significantly induced by tea polyphenols and tea pigments treatments.</p><p><b>CONCLUSION</b>Tea polyphenols and tea pigments induced cell cycle arrest and inhibited cell proliferation by regulating cell cycle regulators.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Phenols
/
Pigments, Biological
/
Polymers
/
Precancerous Conditions
/
Tea
/
Flavonoids
/
RNA, Messenger
/
Proteins
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2002
Type:
Article
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