Effect of Modified Baizhu Powder on Gastrointestinal Functions in Mouse Models with Stomach-cold Functional Dyspepsia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 435-439, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-257615
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of modified Baizhu (Rhizoma Atractylodis Macrocephalae) powder on the gastrointestinal function in mouse models with stomach-cold functional dyspepsia. Meanwhile,the mouse models were administered with Shihu (dendrobium), a traditional Chinese drug with cold nature and flavour, to explore the way via which it exert its effect on specific symptoms. Methods:
Mouse models with stomach-cold functional dyspepsia were established by ice water and ice NaOH. The effects of modified Baizhu powder and dendrobium on mice were observed in terms of water intake, weight change,small intestine propulsion rate, intestinal absorption function, and effects on ghrelin and motilin.</p><p><b>RESULTS</b>The modified Baizhu powder effectively increased food intake, water intake, body weight (P<0.05) and swimming time (P<0.01), increased the small intestine propulsion rate and serum D-xylose content (P<0.05), and up-regulated ghrelin (P<0.05). Also, it showed a trend to down-regulate the motilin, although the change was not statistically significant (P>0.05). In contrast,the use of Shihu aggravated symptoms in the mouse models.Conclusion:
The changes in ghrelin and motilin levels may be the neuro-endocrine mechanisms via which the modified Baizhu powder and Shihu exert their effects on mouse models.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Powders
/
Stomach
/
Motilin
/
Disease Models, Animal
/
Dyspepsia
/
Ghrelin
/
Intestine, Small
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2015
Type:
Article
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