Localized Scleroderma of Lower Extremities:Clinical and Magnetic Resonance Imaging Features / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 392-397, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-257623
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical and musculoskeletal characteristics of localized scleroderma with lower extremities affected.</p><p><b>METHODS</b>All the localized scleroderma patients,who received magnetic resonance (MR ) examinations of affected lower extremities at Peking Union Medical College Hospital from April 2013 to June 2014,were retrospectively reviewed. Their clinical data and laboratory results of antinuclear antibody,anti-double stranded-DNA antibody, and anti-extractable nuclear antigen antibody were collected and analyzed. All the MR examinations were non-contrast imaging using Siemens Skyra 3.0T MR scanner.</p><p><b>RESULTS</b>There were 16 localized scleroderma patients with lower extremities affected, 11 of whom were linear scleroderma, 4 generalized morphea, and 1 deep morphea. Female to male ratio was 12.2. The mean age was 22.5 years. The mean time span was 7.4 years. Four of the 14 patients (28.6%) who received antinuclear antibody test were positive. All the 10 patients who received anti-double stranded-DNA antibody test and the 7 patients who received anti-extractable nuclear antigen antibody test were negative. The most common musculoskeletal MR features were subcutaneous septal thickening (16/16) and fascial thickening (11/16). The thickened speta and fascia could either be hypointenstiy or hyperintensity on turbo inversion recovery magnitude/proton density weighted imaging. Other MR manifestations were intramuscular speta thickening (3/16), muscular abnormal signals (1/16), and bone marrow abnormal signals (2/16).</p><p><b>CONCLUSION</b>Musculoskeletal manifestations of the lower extremities with localized scleroderma can be well revealed using MR imaging.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Scleroderma, Localized
/
Magnetic Resonance Imaging
/
Antibodies, Antinuclear
/
Retrospective Studies
/
Lower Extremity
Type of study:
Observational study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2015
Type:
Article
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