Research Advances in the Role of RAS-GTPase-activating Proteins in Tumors / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 364-369, 2015.
Article
in English
| WPRIM
| ID: wpr-257627
ABSTRACT
A variety of molecules are involved in tumorigenesis,during which the RAS pathway-related molecules play key roles. RAS gene mutations exist in about 30% of human tumors;in some tumors(e.g. pancreatic adenocarcinomas),the mutation rates may rise to 75%-95%. Even in tumors without RAS mutations,the RAS pathway-related molecules can also be highly activated. RAS-GTPase-activating proteins(RASGAPs)are a group of tumor suppressors. They normally turn off RAS pathway by catalyzing the hydrolysis of RAS-GTP. However,the mutation or hypermethylation of their promoters will inactivate their roles and thus provide an alternative mechanism of activating Ras. This article reviews the research advances in the role of RASGAPs in the development of tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Transformation, Neoplastic
/
Genes, ras
/
DNA Methylation
/
Ras GTPase-Activating Proteins
/
Mutation
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2015
Type:
Article
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