Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma
Korean Journal of Pathology
;
: 162-168, 2012.
Article
in English
| WPRIM
| ID: wpr-25783
ABSTRACT
BACKGROUND:
Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma.METHODS:
Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls.RESULTS:
There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035).CONCLUSIONS:
Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Haplotypes
/
Immunoglobulin E
/
Interleukins
/
Polymorphism, Single Nucleotide
/
Gene Frequency
/
Genotype
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2012
Type:
Article
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