The role of human herpesvirus-8 infection in the pathogenesis of multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 81-84, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-258063
ABSTRACT
Multiple myeloma is a B-cell neoplasm characterized by abnormal proliferation and accumulation of monoclonal plasma cells in the bone marrow. Recently some laboratories have detected human herpesvirus-8 (HHV-8) DNA sequences in bone marrow dendritic cells from myeloma patients. It has been suggested that the cytokines expressed by HHV-8 gene, such as vIRF, vIL-8R and vIL-6, may play a role in the pathogenesis of multiple myeloma. However, the majority of European investigators failed to find evidence to confirm this observation. It remains unclear whether HHV-8 is consequentially associated with myeloma or only a regional opportunistic infection. Controversy still focuses on the role of specific HHV-8 strains involved in pathogenesis of multiple myeloma and causality between the
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Virology
/
Dendritic Cells
/
Seroepidemiologic Studies
/
Epidemiology
/
Cytokines
/
Herpesviridae Infections
/
Herpesvirus 8, Human
/
Allergy and Immunology
/
Metabolism
Type of study:
Etiology study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2002
Type:
Article
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