Low Resistin Level is Associated with Poor Hospitalization-Free Survival in Hemodialysis Patients
Journal of Korean Medical Science
;
: 377-381, 2012.
Article
in English
| WPRIM
| ID: wpr-25825
ABSTRACT
Malnutrition and inflammation are related to high rates of morbidity and mortality in hemodialysis patients. Resistin is associated with nutrition and inflammation. We attempted to determine whether resistin levels may predict clinical outcomes in hemodialysis patients. We conducted a prospective evaluation of 100 outpatients on hemodialysis in a single dialysis center (male, 46%; mean age, 53.7 +/- 16.4 yr). We stratified the patients into 4 groups according to quartiles of serum resistin levels. During the 18-month observational period, patients with the lowest quartile of serum resistin levels had poor hospitalization-free survival (log rank test, P = 0.016). After adjustment of all co-variables, patients with the lowest quartile of serum resistin levels had poor hospitalization-free survival, compared with reference resistin levels. Higher levels of interleukin-6 were an independent predictor of poor hospitalization-free survival. In contrast, serum resistin levels were not correlated with interleukin-6 levels. The current data showed that low resistin levels may independently predict poor hospitalization free survival in hemodialysis patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proportional Hazards Models
/
Survival Analysis
/
Prospective Studies
/
Renal Dialysis
/
Interleukin-6
/
Diabetes Complications
/
Resistin
/
Hospitalization
/
Kidney Failure, Chronic
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2012
Type:
Article
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